C-terminal peptides coassemble into Aβ42 oligomers and protect neurons against Aβ42-induced neurotoxicity

Alzheimer's disease (AD) is an age-related disorder that threatens to become an epidemic as the world population ages. Neurotoxic oligomers of Aβ42 are believed to be the main cause of AD; therefore, disruption of Aβ oligomerization is a promising approach for developing therapeutics for AD. Fo...

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Detalhes bibliográficos
Main Authors: Fradinger, Erica A., Monien, Bernhard H., Urbanc, Brigita, Lomakin, Aleksey, Tan, Miao, Li, Huiyuan, Spring, Sean M., Condron, Margaret M., Cruz, Luis, Xie, Cui-Wei, Benedek, George B., Bitan, Gal
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2544597/
https://ncbi.nlm.nih.gov/pubmed/18779585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807163105
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