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Crosspresentation by nonhematopoietic and direct presentation by hematopoietic cells induce central tolerance to myelin basic protein

Central tolerance plays a critical role in eliminating self-reactive T cells specific for peripheral antigens. Here we show that central tolerance of MHC class I-restricted T cells specific for classic myelin basic protein (MBP), a component of the myelin sheath, is mediated by both bone marrow (BM)...

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Bibliografische gegevens
Hoofdauteurs: Perchellet, Antoine, Brabb, Thea, Goverman, Joan M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2008
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2544575/
https://ncbi.nlm.nih.gov/pubmed/18772374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804970105
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