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Viral Infection Triggers Central Nervous System Autoimmunity Via Activation of Dual TCR-Expressing CD8(+) T Cells

Multiple sclerosis (MS) is an inflammatory, demyelinating, central nervous system disease mediated by myelin-specific T cells. Environmental triggers that cause a breakdown of myelin-specific T cell tolerance are unknown. We found that CD8(+) myelin basic protein (MBP)-specific T cell tolerance can...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ji, Qingyong, Perchellet, Antoine, Goverman, Joan M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900379/
https://ncbi.nlm.nih.gov/pubmed/20526343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1888
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