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Neutrophil activation by the tissue factor/Factor VIIa/PAR2 axis mediates fetal death in a mouse model of antiphospholipid syndrome

Women with antiphospholipid syndrome (APS), a condition characterized by the presence of antiphospholipid antibodies (aPL), often suffer pregnancy-related complications, including miscarriage. We have previously shown that C5a induction of tissue factor (TF) expression in neutrophils contributes to...

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Detalhes bibliográficos
Main Authors: Redecha, Patricia, Franzke, Claus-Werner, Ruf, Wolfram, Mackman, Nigel, Girardi, Guillermina
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2542852/
https://ncbi.nlm.nih.gov/pubmed/18802482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36089
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