Inhibition of Human Immunodeficiency Virus Type 1 Replication in Primary Macrophages by Using Tat- or CCR5-Specific Small Interfering RNAs Expressed from a Lentivirus Vector

Although several groups have demonstrated that RNA interference, induced by transfection of small interfering RNA (siRNA) duplexes, can protect cells against a viral challenge in culture, this protection is transient. Here, we describe lentivirus expression vectors that can stably express siRNAs at...

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Detalhes bibliográficos
Main Authors: Lee, Ming-Ta M., Coburn, Glen A., McClure, Myra O., Cullen, Bryan R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC254276/
https://ncbi.nlm.nih.gov/pubmed/14581533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.22.11964-11972.2003
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