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Inhibition of Human Immunodeficiency Virus Replication by a Dual CCR5/CXCR4 Antagonist
Here we report that the N-pyridinylmethyl cyclam analog AMD3451 has antiviral activity against a wide variety of R5, R5/X4, and X4 strains of human immunodeficiency virus type 1 (HIV-1) and HIV-2 (50% inhibitory concentration [IC(50)] ranging from 1.2 to 26.5 μM) in various T-cell lines, CCR5- or CX...
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Main Authors: | , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society for Microbiology
2004
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC524989/ https://ncbi.nlm.nih.gov/pubmed/15542651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.23.12996-13006.2004 |
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