Inhibition of Human Immunodeficiency Virus Replication by a Dual CCR5/CXCR4 Antagonist

Here we report that the N-pyridinylmethyl cyclam analog AMD3451 has antiviral activity against a wide variety of R5, R5/X4, and X4 strains of human immunodeficiency virus type 1 (HIV-1) and HIV-2 (50% inhibitory concentration [IC(50)] ranging from 1.2 to 26.5 μM) in various T-cell lines, CCR5- or CX...

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Bibliographic Details
Main Authors: Princen, Katrien, Hatse, Sigrid, Vermeire, Kurt, Aquaro, Stefano, De Clercq, Erik, Gerlach, Lars-Ole, Rosenkilde, Mette, Schwartz, Thue W., Skerlj, Renato, Bridger, Gary, Schols, Dominique
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC524989/
https://ncbi.nlm.nih.gov/pubmed/15542651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.23.12996-13006.2004
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