Resistance Profile of a Hepatitis C Virus RNA-Dependent RNA Polymerase Benzothiadiazine Inhibitor

Recently, a benzo-1,2,4-thiadiazine antiviral agent (C(21)H(21)N(3)O(4)S; compound 4) was shown to be a potent, highly specific inhibitor of the primary catalytic enzyme of the hepatitis C virus (HCV) replicase complex. In this study, we selected for resistance to confirm the mechanism of action for...

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Detalhes bibliográficos
Main Authors: Nguyen, Tammy T., Gates, Adam T., Gutshall, Lester L., Johnston, Victor K., Gu, Baohua, Duffy, Kevin J., Sarisky, Robert T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC253783/
https://ncbi.nlm.nih.gov/pubmed/14576112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.11.3525-3530.2003
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