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Measurement of pulsatile insulin secretion in the rat: direct sampling from the hepatic portal vein

It has previously been shown that insulin is secreted in discrete secretory bursts by sampling directly from the portal vein in the dog and humans. Deficient pulsatile insulin secretion is the basis for impaired insulin secretion in type 2 diabetes. However, while novel genetically modified disease...

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Main Authors: Matveyenko, Aleksey V., Veldhuis, Johannes D., Butler, Peter C.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2536733/
https://ncbi.nlm.nih.gov/pubmed/18577690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.90335.2008
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