Suppression of Aging in Mice by the Hormone Klotho

A defect in Klotho gene expression in mice accelerates the degeneration of multiple age-sensitive traits. Here, we show that overexpression of Klotho in mice extends life span. Klotho protein functions as a circulating hormone that binds to a cell-surface receptor and represses intracellular signals...

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Detalhes bibliográficos
Main Authors: Kurosu, Hiroshi, Yamamoto, Masaya, Clark, Jeremy D., Pastor, Johanne V., Nandi, Animesh, Gurnani, Prem, McGuinness, Owen P., Chikuda, Hirotaka, Yamaguchi, Masayuki, Kawaguchi, Hiroshi, Shimomura, Iichiro, Takayama, Yoshiharu, Herz, Joachim, Kahn, C. Ronald, Rosenblatt, Kevin P., Kuro-o, Makoto
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2536606/
https://ncbi.nlm.nih.gov/pubmed/16123266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1112766
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