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GFP-TAGGED MUTANT PRION PROTEIN FORMS INTRA-AXONAL AGGREGATES IN TRANSGENIC MICE
A nine-octapeptide insertional mutation in the prion protein (PrP) causes a fatal neurodegenerative disorder in both humans and transgenic mice. To determine the precise cellular localization of this mutant PrP (designated PG14), we have generated transgenic mice expressing PG14-EGFP, a fluorescent...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2536573/ https://ncbi.nlm.nih.gov/pubmed/18514536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2008.03.006 |
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