The Pleiotropic Phenotype of Apc Mutations in the Mouse: Allele Specificity and Effects of the Genetic Background

Familial adenomatous polyposis (FAP) is a human cancer syndrome characterized by the development of hundreds to thousands of colonic polyps and extracolonic lesions including desmoid fibromas, osteomas, epidermoid cysts, and congenital hypertrophy of the pigmented retinal epithelium. Afflicted indiv...

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Main Authors: Halberg, Richard B., Chen, Xiaodi, Amos-Landgraf, James M., White, Alanna, Rasmussen, Kristin, Clipson, Linda, Pasch, Cheri, Sullivan, Ruth, Pitot, Henry C., Dove, William F.
Format: Artigo
Jezik:Inglês
Izdano: Genetics Society of America 2008
Teme:
Investigations
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2535708/
https://ncbi.nlm.nih.gov/pubmed/18723878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.108.091967
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