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TAK1 Regulates Reactive Oxygen Species and Cell Death in Keratinocytes, Which Is Essential for Skin Integrity

Mice with a keratinocyte-specific deletion of Tak1 exhibit severe skin inflammation due to hypersensitivity to tumor necrosis factor (TNF) killing. Here we have examined the mechanisms underlying this hypersensitivity. We found that TAK1 deficiency up-regulates reactive oxygen species (ROS) resultin...

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Autors principals: Omori, Emily, Morioka, Sho, Matsumoto, Kunihiro, Ninomiya-Tsuji, Jun
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533783/
https://ncbi.nlm.nih.gov/pubmed/18606807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804513200
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