Pentalenolactone Biosynthesis. Molecular Cloning and Assignment of Biochemical Function to PtlH, a Non-Heme Iron Dioxygenase of Streptomyces avermitilis

[Image: see text] The hydroxylase encoded by theptlH (SAV2991) gene from the pentalenolactone gene cluster ofStreptomyces avermitilis was cloned by PCR and expressed inEscherichia colias an N-terminal-His(6)-tag protein. Incubation of recombinant PtlH with (±)-1- deoxypentalenic acid (5) in the pres...

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Bibliographic Details
Main Authors:	You, Zheng, Omura, Satoshi, Ikeda, Haruo, Cane, David E.
Format:	Artigo
Language:	Inglês
Published:	2006
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2533727/ https://ncbi.nlm.nih.gov/pubmed/16704250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja061469i
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Pentalenolactone Biosynthesis. Molecular Cloning and Assignment of Biochemical Function to PtlH, a Non-Heme Iron Dioxygenase of Streptomyces avermitilis

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