Structural Examination of Ring-Closing Metathesis-Derived 15-Member Macrocycles as Grb2 SH2 Domain-Binding Tetrapeptide Mimetics

Ring-closing metathesis (RCM) was employed to join carboxy-terminal alkenyl glycine side chains together with vinyl- and allyl-functionality appended to the β-methylene of amino-terminal phosphotyrosyl (pTyr) mimetics. This required the synthesis of a variety of new pTyr mimetics, including a novel...

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Bibliographic Details
Main Authors: Liu, Fa, Worthy, Karen M., Bindu, Lakshman K., Fisher, Robert J., Burke, Terrence R.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533429/
https://ncbi.nlm.nih.gov/pubmed/17990895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo701831q
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