Application of Azide-Alkyne Cycloaddition “Click Chemistry” for the Synthesis of Grb2 SH2 Domain-Binding Macrocycles

Copper (I) promoted [3+2] Huisgen cycloaddition of azides with terminal alkynes was used to prepare triazole-containing macrocycles based on the Grb2 SH2 domain-binding motif, “Pmp-Ac(6) c-Asn”, where Pmp and Ac(6) c stand for 4-phosphonomethylphenylalanine and 1-aminocyclohexanecarboxylic acid, res...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Choi, Won Jun, Shi, Zhen-Dan, Worthy, Karen M., Bindu, Lakshman, Karki, Rajeshri G., Nicklaus, Marc C., Fisher, Robert J., Burke, Terrence R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1624856/
https://ncbi.nlm.nih.gov/pubmed/16908148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2006.08.004
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados