Application of Azide-Alkyne Cycloaddition “Click Chemistry” for the Synthesis of Grb2 SH2 Domain-Binding Macrocycles

Copper (I) promoted [3+2] Huisgen cycloaddition of azides with terminal alkynes was used to prepare triazole-containing macrocycles based on the Grb2 SH2 domain-binding motif, “Pmp-Ac(6) c-Asn”, where Pmp and Ac(6) c stand for 4-phosphonomethylphenylalanine and 1-aminocyclohexanecarboxylic acid, res...

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Detaylı Bibliyografya
Asıl Yazarlar: Choi, Won Jun, Shi, Zhen-Dan, Worthy, Karen M., Bindu, Lakshman, Karki, Rajeshri G., Nicklaus, Marc C., Fisher, Robert J., Burke, Terrence R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2006
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1624856/
https://ncbi.nlm.nih.gov/pubmed/16908148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2006.08.004
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