Ribosome-templated azide–alkyne cycloadditions: synthesis of potent macrolide antibiotics by in situ click chemistry

Over half of all antibiotics target the bacterial ribosome—Nature's complex, 2.5 MDa nanomachine responsible for decoding mRNA and synthesizing proteins. Macrolide antibiotics, exemplified by erythromycin, bind the 50S subunit with nM affinity and inhibit protein synthesis by blocking the passa...

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Udgivet i:J Am Chem Soc
Main Authors: Glassford, Ian, Teijaro, Christiana N., Daher, Samer S., Weil, Amy, Small, Meagan C., Redhu, Shiv K., Colussi, Dennis J., Jacobson, Marlene A., Childers, Wayne E., Buttaro, Bettina, Nicholson, Allen W., MacKerell, Alexander D., Cooperman, Barry S., Andrade, Rodrigo B.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785600/
https://ncbi.nlm.nih.gov/pubmed/26878192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b13008
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