Discovery of thioether-bridged cyclic pentapeptides binding to Grb2-SH2 domain with high affinity

Blocking the interaction between phosphotyrosine (pTyr)-containing activated receptors and the Src homology 2 (SH2) domain of the growth factor receptor-bound protein 2 (Grb 2) is considered to be an effective and non-cytotoxic strategy to develop new anti-proliferate agents due to its potential to...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Jiang, Sheng, Liao, Chenzhong, Bindu, Lakshman, Yin, Biaolin, Worthy, Karen W., Fisher, Robert J., Burke, Terrence R., Nicklaus, Marc C., Roller, Peter P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7291730/
https://ncbi.nlm.nih.gov/pubmed/19362470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.03.134
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