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The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning

The oxazolidinones represent the first new class of antibiotics to enter into clinical usage within the past 30 years, but their binding site and mechanism of action has not been fully characterized. We have determined the crystal structure of the oxazolidinone linezolid bound to the Deinococcus rad...

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書誌詳細
主要な著者: Wilson, Daniel N., Schluenzen, Frank, Harms, Joerg M., Starosta, Agata L., Connell, Sean R., Fucini, Paola
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2008
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オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533191/
https://ncbi.nlm.nih.gov/pubmed/18757750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804276105
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