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The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning
The oxazolidinones represent the first new class of antibiotics to enter into clinical usage within the past 30 years, but their binding site and mechanism of action has not been fully characterized. We have determined the crystal structure of the oxazolidinone linezolid bound to the Deinococcus rad...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2533191/ https://ncbi.nlm.nih.gov/pubmed/18757750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804276105 |
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