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Improving the Antigenicity of sTn antigen by Modification of Its Sialic Acid Residue for Development of Glycoconjugate Cancer Vaccines

Sialyl Tn (sTn) antigen is a sialylated disaccharide abundantly expressed by many tumors. To search for effective cancer immunotherapies based on sTn antigen, this work designed and synthesized a series of unnatural N-acyl derivatives of sTn and studied their immunological property. For this purpose...

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Autori principali: Wu, Jian, Guo, Zhongwu
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2532825/
https://ncbi.nlm.nih.gov/pubmed/17105234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc060103s
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