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Synthetic and Immunological Studies of 5′-N-phenylacetyl sTn to Develop Carbohydrate-Based Cancer Vaccines and to Explore the Impacts of Linkage between Carbohydrate Antigens and Carrier Proteins

5′-N-Phenylacetyl sTn (sTnNPhAc), an unnatural derivative of sTn antigen expressed by many tumors, and its α-linked protein conjugates were prepared and investigated to explore glycoconjugate cancer vaccines. sTnNPhAcα-KLH elicited a robust T cell-dependent immunity. The antiserum derived from sTnNP...

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Autors principals: Wang, Qianli, Ekanayaka, Sandamali Amarasingha, Wu, Jian, Zhang, Junping, Guo, Zhongwu
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652678/
https://ncbi.nlm.nih.gov/pubmed/18816108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc800243f
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