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Synthetic and Immunological Studies of 5′-N-phenylacetyl sTn to Develop Carbohydrate-Based Cancer Vaccines and to Explore the Impacts of Linkage between Carbohydrate Antigens and Carrier Proteins
5′-N-Phenylacetyl sTn (sTnNPhAc), an unnatural derivative of sTn antigen expressed by many tumors, and its α-linked protein conjugates were prepared and investigated to explore glycoconjugate cancer vaccines. sTnNPhAcα-KLH elicited a robust T cell-dependent immunity. The antiserum derived from sTnNP...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2652678/ https://ncbi.nlm.nih.gov/pubmed/18816108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc800243f |
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