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Scrapie-infected murine neuroblastoma cells produce protease-resistant prion proteins.

Scrapie and Creutzfeldt-Jakob disease are transmissible, degenerative neurological diseases caused by prions. Considerable evidence argues that prions contain protease-resistant sialoglycoproteins, designated PrPSc, encoded by a cellular gene. The prion protein (PrP) gene also encodes a normal cellu...

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Main Authors: Butler, D A, Scott, M R, Bockman, J M, Borchelt, D R, Taraboulos, A, Hsiao, K K, Kingsbury, D T, Prusiner, S B
格式: Artigo
語言:Inglês
出版: 1988
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC253182/
https://ncbi.nlm.nih.gov/pubmed/3282080
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