Variation in homeodomain DNA-binding revealed by high-resolution analysis of sequence preferences

Most homeodomains are unique within a genome, yet many are highly conserved across vast evolutionary distances, implying strong selection on their precise DNA-binding specificities. We determined the binding preferences of the majority (168) of mouse homeodomains to all possible 8-base sequences, re...

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Autors principals: Berger, Michael F., Badis, Gwenael, Gehrke, Andrew R., Talukder, Shaheynoor, Philippakis, Anthony A., Peña-Castillo, Lourdes, Alleyne, Trevis M., Mnaimneh, Sanie, Botvinnik, Olga B., Chan, Esther T., Khalid, Faiqua, Zhang, Wen, Newburger, Daniel, Jaeger, Savina, Morris, Quaid D., Bulyk, Martha L., Hughes, Timothy R.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2531161/
https://ncbi.nlm.nih.gov/pubmed/18585359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.05.024
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