The juxtaposition of a promoter with a locus control region transcriptional domain activates gene expression

Nonlinear chromatin configurations can juxtapose widely separated elements within a genomic locus; however, it remains unclear how these structures are established and contribute to transcriptional control. A 5′-remote locus control region (LCR) regulates the human growth hormone (hGH-N) gene. HSI,...

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Bibliographische Detailangaben
Hauptverfasser: Ho, Yugong, Tadevosyan, Aleksey, Liebhaber, Stephen A, Cooke, Nancy E
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2008
Schlagworte:
Scientific Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529346/
https://ncbi.nlm.nih.gov/pubmed/18636089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.126
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