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DNase I Hypersensitive Site II of the Human Growth Hormone Locus Control Region Mediates an Essential and Distinct Long-range Enhancer Function

Locus control regions (LCRs) comprise sets of DNA elements capable of establishing autonomous chromatin domains that support robust and physiologically appropriate expression of target genes, often working over extensive distances. Human growth hormone (hGH-N) expression in the pituitary is under th...

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Détails bibliographiques
Auteurs principaux: Fleetwood, Margaret R., Ho, Yugong, Cooke, Nancy E., Liebhaber, Stephen A.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408159/
https://ncbi.nlm.nih.gov/pubmed/22669946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.365825
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