DNase I Hypersensitive Site II of the Human Growth Hormone Locus Control Region Mediates an Essential and Distinct Long-range Enhancer Function

Locus control regions (LCRs) comprise sets of DNA elements capable of establishing autonomous chromatin domains that support robust and physiologically appropriate expression of target genes, often working over extensive distances. Human growth hormone (hGH-N) expression in the pituitary is under th...

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Bibliographische Detailangaben
Hauptverfasser: Fleetwood, Margaret R., Ho, Yugong, Cooke, Nancy E., Liebhaber, Stephen A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Gene Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408159/
https://ncbi.nlm.nih.gov/pubmed/22669946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.365825
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