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Replica exchange simulations of transient encounter complexes in protein–protein association

Recent paramagnetic relaxation enhancement (PRE) studies on several weakly interacting protein complexes have unequivocally demonstrated the existence of transient encounter complexes. Here, we present a computational method to study protein–protein binding by creating equilibrium ensembles that inc...

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Detalhes bibliográficos
Main Authors: Kim, Young C., Tang, Chun, Clore, G. Marius, Hummer, Gerhard
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529066/
https://ncbi.nlm.nih.gov/pubmed/18728193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802460105
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