15-Deoxy-Δ(12,14)-prostaglandin J(2) Impairs Phosphatidylcholine Synthesis and Induces Nuclear Accumulation of Thiol-modified Cytidylyltransferase

Synthesis of phosphatidylcholine, the major phospholipid of animal cell membranes, requires the key enzyme cytidylyltransferase (CCTα). Cysteine sulfhydryls within CCTα are needed for full catalytic activity. Here we show that prostaglandin 15-deoxy-Δ(12,14)-PGJ(2) (15d-PGJ(2)) inactivates CCTα by i...

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Détails bibliographiques
Auteurs principaux: Ryan, Alan J., Chen, Bill B., Vennalaganti, Prashanth R., Henderson, Florita C., Tephly, Linda A., Carter, A. Brent, Mallampalli, Rama K.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2008
Sujets:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529000/
https://ncbi.nlm.nih.gov/pubmed/18614529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801167200
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