15-Deoxy-Δ(12,14)-prostaglandin J(2) Impairs Phosphatidylcholine Synthesis and Induces Nuclear Accumulation of Thiol-modified Cytidylyltransferase

Synthesis of phosphatidylcholine, the major phospholipid of animal cell membranes, requires the key enzyme cytidylyltransferase (CCTα). Cysteine sulfhydryls within CCTα are needed for full catalytic activity. Here we show that prostaglandin 15-deoxy-Δ(12,14)-PGJ(2) (15d-PGJ(2)) inactivates CCTα by i...

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Detalhes bibliográficos
Main Authors: Ryan, Alan J., Chen, Bill B., Vennalaganti, Prashanth R., Henderson, Florita C., Tephly, Linda A., Carter, A. Brent, Mallampalli, Rama K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529000/
https://ncbi.nlm.nih.gov/pubmed/18614529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801167200
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