TLR ligand–induced podosome disassembly in dendritic cells is ADAM17 dependent

Toll-like receptor (TLR) signaling induces a rapid reorganization of the actin cytoskeleton in cultured mouse dendritic cells (DC), leading to enhanced antigen endocytosis and a concomitant loss of filamentous actin–rich podosomes. We show that as podosomes are lost, TLR signaling induces prominent...

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Detalhes bibliográficos
Main Authors: West, Michele A., Prescott, Alan R., Chan, Kui Ming, Zhou, Zhongjun, Rose-John, Stefan, Scheller, Jürgen, Watts, Colin
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2008
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2528573/
https://ncbi.nlm.nih.gov/pubmed/18762577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200801022
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