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Broad expression of the FoxP3 locus in epithelial cells: A caution against an early interpretation of fatal inflammatory diseases following in vivo depletion of FoxP3-expressing cells
Dogma that the Treg prevents catastrophic autoimmunity throughout the lifespan relies on the assumption that the FoxP3 locus is transcribed exclusively in Treg. To test the assumption, we used the Rag2(−/−) and the Rag2(−/−) mice with the Scurfy mutation (FoxP3(sf/y) or FoxP3(sf/sf)) to evaluate Fox...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2527697/ https://ncbi.nlm.nih.gov/pubmed/18390696 |
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