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FOXP3 Up-regulates p21 Expression by Site-specific Inhibition of Histone Deacetylase 2/4 Association to the Locus

p21-loss has been implicated in conferring oncogenic activity to known tumor suppressor gene KLF4 and cancer drug tamoxifen. Regulators of p21 therefore play critical roles in tumorigenesis. Here we report that X-linked tumor suppressor FOXP3 is essential for p21 expression in normal epithelia and t...

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Bibliografske podrobnosti
Main Authors: Liu, Runhua, Wang, Lizhong, Chen, Guoyun, Katoh, Hiroto, Chen, Chong, Liu, Yang, Zheng, Pan
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715174/
https://ncbi.nlm.nih.gov/pubmed/19276356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-3717
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