The Difficult Case of Crystallization and Structure Solution for the ParC55 Breakage-Reunion Domain of Topoisomerase IV from Streptococcus pneumoniae

BACKGROUND: Streptococcus pneumoniae is the major cause of community-acquired pneumonia and is also associated with bronchitis, meningitis, otitis and sinusitis. The emergence and increasing prevalence of resistance to penicillin and other antibiotics has led to interest in other anti-pneumonococcal...

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Bibliographic Details
Main Authors: Sohi, Maninder K., Veselkov, Dennis A., Laponogov, Ivan, Pan, Xiao-Su, Fisher, L. Mark, Sanderson, Mark R.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2008
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527675/
https://ncbi.nlm.nih.gov/pubmed/18787651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003201
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