High-resolution array copy number analyses for detection of deletion, gain, amplification and copy-neutral LOH in primary neuroblastoma tumors: Four cases of homozygous deletions of the CDKN2A gene

BACKGROUND: Neuroblastoma is a very heterogeneous pediatric tumor of the sympathetic nervous system showing clinically significant patterns of genetic alterations. Favorable tumors usually have near-triploid karyotypes with few structural rearrangements. Aggressive stage 4 tumors often have near-dip...

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Bibliografiske detaljer
Main Authors:	Carén, Helena, Erichsen, Jennie, Olsson, Linda, Enerbäck, Charlotta, Sjöberg, Rose-Marie, Abrahamsson, Jonas, Kogner, Per, Martinsson, Tommy
Format:	Artigo
Sprog:	Inglês
Udgivet:	BioMed Central 2008
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2527340/ https://ncbi.nlm.nih.gov/pubmed/18664255 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-9-353
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High-resolution array copy number analyses for detection of deletion, gain, amplification and copy-neutral LOH in primary neuroblastoma tumors: Four cases of homozygous deletions of the CDKN2A gene

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