Mutation in the polyomavirus genome that activates the properties of large T associated with neoplastic transformation.
We have constructed a polyomavirus mutant genome which exhibits an increased immortalization potential when transfected into primary rat embryo fibroblasts. The mutation is a 30-base-pair deletion (nucleotides 1367 through 1396) that inactivates the transforming potential of middle T but activates s...
Uloženo v:
| Vydáno v: | J Virol |
|---|---|
| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Microbiology (ASM)
1986
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC252711/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3001342/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.57.1.165-172.1986 |
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