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Mutation in the polyomavirus genome that activates the properties of large T associated with neoplastic transformation.

We have constructed a polyomavirus mutant genome which exhibits an increased immortalization potential when transfected into primary rat embryo fibroblasts. The mutation is a 30-base-pair deletion (nucleotides 1367 through 1396) that inactivates the transforming potential of middle T but activates s...

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Detalhes bibliográficos
Main Authors: Asselin, C, Vass-Marengo, J, Bastin, M
Formato: Artigo
Idioma:Inglês
Publicado em: 1986
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC252711/
https://ncbi.nlm.nih.gov/pubmed/3001342
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