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Polyomavirus large T mutants affected in retinoblastoma protein binding are defective in immortalization.

To clarify the relationship between the various activities of the polyomavirus large T antigen and the contribution of this oncogene to neoplastic transformation, we constructed a series of mutants with small deletions or single-amino-acid substitutions in two separate regions of the protein. These...

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Publicat a:J Virol
Autors principals: Larose, A, Dyson, N, Sullivan, M, Harlow, E, Bastin, M
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 1991
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240580/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2016761/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.65.5.2308-2313.1991
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