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Multiplicity of DNA Single-Strand Breaks Produced in pUC18 Exposed to the Direct Effects of Ionizing Radiation

The transition of plasmid DNA from a supercoiled to an open circle conformation, as detected by gel electrophoresis, affords an extraordinarily sensitive method for detecting single-strand breaks (SSBs), one measure of deoxyribose damage. To determine the yield of SSBs, G(ssb), by this method, it is...

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Detalhes bibliográficos
Main Authors: Sharma, Kiran Kumar K., Milligan, Jamie R., Bernhard, William A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527055/
https://ncbi.nlm.nih.gov/pubmed/18666814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR1277.1
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