Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity

A new regulatory T (T reg) cell–specific, FoxP3-GFP-hCre bacterial artificial chromosome transgenic mouse was crossed to a conditional Dicer knockout (KO) mouse strain to analyze the role of microRNAs (miRNAs) in the development and function of T reg cells. Although thymic T reg cells developed norm...

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Bibliografiska uppgifter
Huvudupphovsmän: Zhou, Xuyu, Jeker, Lukas T., Fife, Brian T., Zhu, Shirley, Anderson, Mark S., McManus, Michael T., Bluestone, Jeffrey A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2008
Ämnen:
Brief Definitive Reports
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2526194/
https://ncbi.nlm.nih.gov/pubmed/18725525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20080707
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