Inhibition of Autoimmune Diabetes in NOD Mice by miRNA Therapy

Autoimmune destruction of the pancreatic islets in Type 1 diabetes is mediated by both increased proinflammatory (Teff) and decreased regulatory (Treg) T lymphocytes resulting in a significant decrease in the Treg:Teff ratio. The non-obese diabetic (NOD) mouse is an excellent in vivo model for testi...

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Udgivet i:PLoS One
Main Authors: Wang, Duncheng, Shanina, Iryna, Toyofuku, Wendy M., Horwitz, Marc S., Scott, Mark D.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4692265/
https://ncbi.nlm.nih.gov/pubmed/26674203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145179
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