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Indiscriminate Binding by OMP Decarboxylase of UMP Derivatives with Bulky Anionic C(6)-Substituents

OMP decarboxylase appears to act upon its substrate without the intervention of metals or other cofactors and without the formation of covalent bonds between the enzyme and the substrate. Crystallographic information indicates that substrate binding forces the substrate’s scissile carboxylate group...

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Detalhes bibliográficos
Main Authors: Lewis, Charles A., Wolfenden, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2525794/
https://ncbi.nlm.nih.gov/pubmed/17967036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi700796t
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