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Revisiting a Classic Approach to the Aspidosperma Alkaloids: An Intramolecular Schmidt Reaction-Mediated Synthesis of (+)-Aspidospermidine
A total synthesis of (+)-aspidospermidine (1) is described. The key reactions used in the synthesis of this pentacyclic Aspidosperma alkaloid were a deracemizing imine alkylation/Robinson annulation sequence, a selective “redox ketalization” and an intramolecular Schmidt reaction. A Fischer indoliza...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2005
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2525662/ https://ncbi.nlm.nih.gov/pubmed/16355981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo051212n |
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