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Revisiting a Classic Approach to the Aspidosperma Alkaloids: An Intramolecular Schmidt Reaction-Mediated Synthesis of (+)-Aspidospermidine

A total synthesis of (+)-aspidospermidine (1) is described. The key reactions used in the synthesis of this pentacyclic Aspidosperma alkaloid were a deracemizing imine alkylation/Robinson annulation sequence, a selective “redox ketalization” and an intramolecular Schmidt reaction. A Fischer indoliza...

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Detalhes bibliográficos
Main Authors: Iyengar, Rajesh, Schildknegt, Klaas, Morton, Martha, Aubé, Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2525662/
https://ncbi.nlm.nih.gov/pubmed/16355981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo051212n
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