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NGF and BDNF signaling control amyloidogenic route and Aβ production in hippocampal neurons
Here, we report that interruption of NGF or BDNF signaling in hippocampal neurons rapidly activates the amyloidogenic pathway and causes neuronal apoptotic death. These events are associated with an early intracellular accumulation of PS1 N-terminal catalytic subunits and of APP C-terminal fragments...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2525562/ https://ncbi.nlm.nih.gov/pubmed/18728191 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806133105 |
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