NGF and BDNF signaling control amyloidogenic route and Aβ production in hippocampal neurons

Here, we report that interruption of NGF or BDNF signaling in hippocampal neurons rapidly activates the amyloidogenic pathway and causes neuronal apoptotic death. These events are associated with an early intracellular accumulation of PS1 N-terminal catalytic subunits and of APP C-terminal fragments...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Matrone, Carmela, Ciotti, Maria Teresa, Mercanti, Delio, Marolda, Roberta, Calissano, Pietro
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2008
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2525562/
https://ncbi.nlm.nih.gov/pubmed/18728191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806133105
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