Loading...

Tyrosine kinase nerve growth factor receptor switches from prosurvival to proapoptotic activity via Abeta-mediated phosphorylation

The present study shows that increased Abeta production in hippocampal neurons, due to a failure of NGF signal, induces an unexpected phosphorylation of tyrosine kinase receptor A (TrkA), followed by activation of the phospholipase C γ (PLCγ) pathway and neuronal death. Such phosphorylation seems ca...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Matrone, C., Marolda, R., Ciafrè, S., Ciotti, M. T., Mercanti, D., Calissano, P.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699376/
https://ncbi.nlm.nih.gov/pubmed/19549834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0904998106
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!