NGF and BDNF signaling control amyloidogenic route and Aβ production in hippocampal neurons

Here, we report that interruption of NGF or BDNF signaling in hippocampal neurons rapidly activates the amyloidogenic pathway and causes neuronal apoptotic death. These events are associated with an early intracellular accumulation of PS1 N-terminal catalytic subunits and of APP C-terminal fragments...

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Bibliografische gegevens
Hoofdauteurs: Matrone, Carmela, Ciotti, Maria Teresa, Mercanti, Delio, Marolda, Roberta, Calissano, Pietro
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2008
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2525562/
https://ncbi.nlm.nih.gov/pubmed/18728191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806133105
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