A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5

Systemic lupus erythematosus (SLE) is the prototype autoimmune disease where genes regulated by type I interferon (IFN) are over-expressed and contribute to the disease pathogenesis. Because signal transducer and activator of transcription 4 (STAT4) plays a key role in the type I IFN receptor signal...

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Autors principals: Sigurdsson, Snaevar, Nordmark, Gunnel, Garnier, Sophie, Grundberg, Elin, Kwan, Tony, Nilsson, Olof, Eloranta, Maija-Leena, Gunnarsson, Iva, Svenungsson, Elisabet, Sturfelt, Gunnar, Bengtsson, Anders A., Jönsen, Andreas, Truedsson, Lennart, Rantapää-Dahlqvist, Solbritt, Eriksson, Catharina, Alm, Gunnar, Göring, Harald H.H., Pastinen, Tomi, Syvänen, Ann-Christine, Rönnblom, Lars
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2008
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2525501/
https://ncbi.nlm.nih.gov/pubmed/18579578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn184
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