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CONCERTED CONFORMATIONAL EFFECTS OF Ca (2+) AND ATP ARE REQUIRED FOR ACTIVATION OF SEQUENTIAL REACTIONS IN THE Ca(2+) ATPase (SERCA) CATALYTIC CYCLE
We relate solution behavior to the crystal structure of the Ca(2+) ATPase (SERCA). We find that nucleotide binding occurs with high affinity through interaction of the adenosine moiety with the N domain, even in the absence of Ca(2+) and Mg(2+), or to the closed conformation stabilized by thapsigarg...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2006
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2525454/ https://ncbi.nlm.nih.gov/pubmed/17105196 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi061255d |
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