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CONCERTED CONFORMATIONAL EFFECTS OF Ca (2+) AND ATP ARE REQUIRED FOR ACTIVATION OF SEQUENTIAL REACTIONS IN THE Ca(2+) ATPase (SERCA) CATALYTIC CYCLE

We relate solution behavior to the crystal structure of the Ca(2+) ATPase (SERCA). We find that nucleotide binding occurs with high affinity through interaction of the adenosine moiety with the N domain, even in the absence of Ca(2+) and Mg(2+), or to the closed conformation stabilized by thapsigarg...

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Hlavní autoři: Inesi, Giuseppe, Lewis, David, Ma, Hailun, Prasad, Anand, Toyoshima, Chikashi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2525454/
https://ncbi.nlm.nih.gov/pubmed/17105196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi061255d
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