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Cooperative setting for long-range linkage of Ca(2+) binding and ATP synthesis in the Ca(2+) ATPase.

High-affinity and cooperative binding of two Ca(2+) per ATPase (SERCA) occurs within the membrane-bound region of the enzyme. Direct measurements of binding at various Ca(2+) concentrations demonstrate that site-directed mutations within this region interfere selectively with Ca(2+) occupancy of eit...

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Bibliografiske detaljer
Main Authors: Inesi, Giuseppe, Zhang, Zhongsen, Lewis, David
Format: Artigo
Sprog:Inglês
Udgivet: 2002
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1302322/
https://ncbi.nlm.nih.gov/pubmed/12414670
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