Der3p/Hrd1p Is Required for Endoplasmic Reticulum-associated Degradation of Misfolded Lumenal and Integral Membrane Proteins

We have studied components of the endoplasmic reticulum (ER) proofreading and degradation system in the yeast Saccharomyces cerevisiae. Using a der3–1 mutant defective in the degradation of a mutated lumenal protein, carboxypeptidase yscY (CPY*), a gene was cloned which encodes a 64-kDa protein of t...

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Εκδόθηκε σε:	Mol Biol Cell
Κύριοι συγγραφείς:	Bordallo, Javier, Plemper, Richard K., Finger, Andreas, Wolf, Dieter H.
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	American Society for Cell Biology 1998
Θέματα:	Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC25244/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9437001/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.9.1.209
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